Ichiro Hisatome Selected Research

Hyperuricemia

6/2022	C-reactive Protein Levels and Cardiovascular Outcomes After Febuxostat Treatment in Patients with Asymptomatic Hyperuricemia: Post-hoc Analysis of a Randomized Controlled Study.
2/2022	Effect of febuxostat on clinical outcomes in patients with hyperuricemia and cardiovascular disease.
1/2022	Lactobacillus gasseri PA-3 reduces serum uric acid levels in patients with marginal hyperuricemia.
1/2021	Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　- Japanese Guideline on the Management of Asymptomatic Hyperuricemia.
1/2021	Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia.
7/2020	Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock.
1/2020	Recent approaches to gout drug discovery: an update.
11/2019	Hyperuricemia as a Risk Factor for Atrial Fibrillation Due to Soluble and Crystalized Uric Acid.
1/2019	High rate of calories from protein is associated with higher prevalence of hypertension.
1/2018	Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study.

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Ichiro Hisatome Research Topics

Disease

27	Hyperuricemia 06/2022 - 01/2003
22	Heart Failure 01/2022 - 03/2002
20	Hypertension (High Blood Pressure) 01/2021 - 09/2002
11	Cardiovascular Diseases (Cardiovascular Disease) 02/2022 - 09/2003
11	Insulin Resistance 01/2021 - 03/2007
10	Ischemia 01/2018 - 09/2003
8	Chronic Renal Insufficiency 01/2021 - 12/2014
7	Gout 02/2022 - 01/2010
7	Myocardial Infarction 01/2022 - 08/2005
7	Hypoxia (Hypoxemia) 01/2022 - 06/2004
7	Dyslipidemias (Dyslipidemia) 03/2020 - 08/2014
6	Inflammation (Inflammations) 06/2022 - 07/2009
6	Atrial Fibrillation 11/2019 - 08/2009
5	Diabetes Mellitus 01/2019 - 09/2002
4	Non-alcoholic Fatty Liver Disease 01/2021 - 06/2010
4	Reperfusion Injury 01/2020 - 09/2003
4	Obesity 11/2017 - 06/2008
3	Thrombosis (Thrombus) 11/2020 - 11/2004
3	Renal hypouricemia 04/2019 - 01/2004
3	Left Ventricular Dysfunction 01/2018 - 09/2003
3	Long QT Syndrome 10/2016 - 02/2011
3	Disease Progression 05/2011 - 11/2004
2	Cardiac Arrhythmias (Arrythmia) 10/2022 - 11/2011
2	Juvenile gout 06/2022 - 08/2015
2	Type 2 Diabetes Mellitus (MODY) 01/2022 - 01/2019
2	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 05/2011
2	Bradycardia 11/2019 - 01/2019
2	Hepatitis 10/2018 - 03/2006
2	Colitis 10/2018 - 04/2005
2	Dehydration (Water Stress) 01/2017 - 04/2008
2	Long Qt Syndrome 2 11/2016 - 12/2013
2	Hyperglycemia 01/2014 - 04/2008
2	Lung Injury 04/2013 - 04/2007
2	Hemorrhage 04/2013 - 08/2005
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 11/2011 - 12/2008
2	Thyroiditis 11/2009 - 02/2009
2	Thyroid Diseases (Thyroid Disease) 02/2009 - 08/2004
2	Graves Disease (Basedow Disease) 02/2009 - 08/2004

Drug/Important Bio-Agent (IBA)

45	Uric Acid (Urate)IBA 07/2022 - 01/2004
10	Proteins (Proteins, Gene)FDA Link 06/2022 - 07/2002
7	Xanthine OxidaseIBA 01/2017 - 09/2003
6	Febuxostat FDA Link 06/2022 - 01/2017
6	Messenger RNA (mRNA)IBA 01/2022 - 04/2007
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 06/2010
6	Insulin (Novolin)FDA Link 01/2021 - 01/2010
6	purineIBA 08/2015 - 09/2003
5	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 08/2013
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 01/2014
4	FYX-051IBA 01/2021 - 12/2014
4	Blood Glucose (Blood Sugar)IBA 05/2020 - 11/2017
4	SodiumIBA 05/2020 - 12/2009
4	SaltsIBA 05/2020 - 04/2008
4	Antihypertensive Agents (Antihypertensives)IBA 08/2014 - 09/2002
4	CytokinesIBA 02/2014 - 01/2003
3	InflammasomesIBA 07/2022 - 11/2019
3	C-Reactive ProteinIBA 06/2022 - 08/2002
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2022 - 03/2002
3	HypoxanthineIBA 01/2022 - 09/2003
3	Uricosuric AgentsIBA 01/2020 - 01/2010
3	Pharmaceutical PreparationsIBA 01/2020 - 01/2003
3	AntioxidantsIBA 11/2019 - 07/2016
3	ORALIT (ORS)IBA 01/2019 - 08/2014
3	Proteasome Endopeptidase Complex (Proteasome)IBA 09/2015 - 03/2003
3	Losartan (Cozaar)FDA LinkGeneric 01/2014 - 02/2004
3	Inosine Monophosphate (IMP)IBA 04/2013 - 09/2003
3	Adenosine Monophosphate (AMP)IBA 04/2013 - 09/2003
3	RetinoidsIBA 05/2011 - 06/2010
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 11/2010 - 12/2002
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2010 - 01/2003
2	UromodulinIBA 06/2022 - 08/2015
2	XanthineIBA 01/2022 - 09/2003
2	EnzymesIBA 01/2020 - 03/2006
2	cilnidipineIBA 01/2020 - 01/2012
2	Adrenergic Agents (Adrenergic Drugs)IBA 01/2019 - 01/2015
2	Angiotensin IIIBA 12/2018 - 11/2010
2	Irbesartan FDA LinkGeneric 12/2018 - 01/2014
2	Biological ProductsIBA 11/2018 - 12/2005
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 09/2016 - 02/2010
2	potassium oxonateIBA 01/2016 - 05/2014
2	UbiquitinIBA 09/2015 - 12/2008
2	AlbuminsIBA 12/2014 - 12/2009
2	DiureticsIBA 02/2014 - 06/2007
2	Furosemide (Lasix)FDA LinkGeneric 02/2014 - 11/2004
2	AMP Deaminase (Myoadenylate Deaminase)IBA 04/2013 - 04/2007
2	Carrier Proteins (Binding Protein)IBA 11/2011 - 12/2008
2	Cardiac MyosinsIBA 11/2011 - 12/2008
2	NG-Nitroarginine Methyl Ester (L-NAME)IBA 05/2011 - 11/2009
2	ThioredoxinsIBA 05/2011 - 03/2006
2	CatalaseIBA 12/2010 - 03/2006
2	BenzbromaroneIBA 01/2010 - 01/2004
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 10/2009 - 04/2005
2	sodium-iodide symporter (sodium iodide symporter)IBA 02/2009 - 07/2002
2	AutoantigensIBA 02/2009 - 08/2004
2	AntibodiesIBA 02/2009 - 08/2004
2	Adenosine (Adenocard)FDA LinkGeneric 09/2007 - 12/2006
2	Allopurinol (Remid)FDA LinkGeneric 11/2006 - 09/2003

Therapy/Procedure

12	Therapeutics 01/2022 - 09/2003
3	Transplantation 12/2018 - 02/2013
2	Catheter Ablation 08/2009 - 07/2004
2	Ligation 04/2007 - 11/2006